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Revisiting and Repurposing the Double Helix

Date: Monday, October 7, 2019 16:00 - 17:00
Speaker: Taekjip Ha (Johns Hopkins University)
Location: Raiffeisen Lecture Hall, Central Building
Series: Institute colloquium
Host: Johann Danzl
Contact: Arinya Eller
Central building lecture hall

Abstract:

DNA is an iconic molecule that forms a double helical structure, providing the basis for genetic inheritance, and its physical properties have been studied for decades. In this talk, I will present evidence that sequence and methylation dependent physical properties of DNA such as flexibility and self-association may be important for biological functions. In addition, I will present a new application of DNA where mechanical modulations of cell behavior can be studied at the single molecule level using rupturable DNA tethers.

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