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Tension-based vertex model of organoids

Date: Tuesday, October 23, 2018 10:00 - 11:15
Speaker: Primoz Ziherl (University of Ljubljana and Jozef Stefan Institute, Ljubljana, Slovenia)
Location: Mondi Seminar Room 1, Central Building
Series: Physical Sciences Seminar
Host: Edouard Hannezo
Contact: ALESCH Louis

We theoretically explore the shape of small closed epithelial shells as models of organoids. Using the 3D vertex model based on the surface energy of individual cells, we compute the shape of shellsfully fluidised by active T1 transitions for various apico-basal differential tensions, and we find spherical, ellipsoidal, branchedand stomatocytic shapes. By building on the analogy with lipid vesicles, we characterize the shapes by reduced volume and spontaneous curtvature and we arrange them in the phase diagram.These results shed light on possible non-specific processes that shape the organoids.
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