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How do proteins evolve?

Date: Tuesday, December 18, 2018 14:00 - 15:00
Speaker: Dan S. Tawfik (Weizmann Institute of Science)
Location: Seminar Room, Lab Building East
Series: Life Sciences Seminar
Host: Fyodor Kondrashov
Contact: MALLY Alexandra
Lab building east seminar room

I will describe findings and models regarding how new proteins functions evolve, via gradual, small changes in sequence and structure. However, the mechanisms of such evolutionary micro-transitions do not explain the macro evolutionary transitions how (and whether) did proteins emerge de novo? The size, structural complexity, and functional near-perfection of proteins, makes this Q particularly daunting. In the second part of my talk I will discuss our findings with respect to the de novo emergence of functional, globular proteins from short peptides, and specifically, new insight regarding the emergence of the earliest proteins.
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