Although males and females largely share a single genome, in many species they can look and act completely different. How are these different morphologies encoded at the molecular level? What is the role of sex chromosomes, the only part of the genome that differs between the sexes? And how do genomes evolve when traits that are good for one sex can be bad for the other (i.e. there is sexual conflict)? Our lab addresses these questions using genomics and transcriptomics in a variety of model and nonmodel organisms, and I will highlight some of our recent projects and results.