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Understanding Ras Sensitivity to Mutation by High-Throughput Mutagenesis

Date: Tuesday, June 4, 2019 14:00 - 15:30
Speaker: John Kuriyan (Howard Hughes Medical Institute Departments of Molecular & Cell Biology and Department of Chemistry, UC Berkely)
Location: Big Seminar room Ground floor / Office Bldg West (I21.EG.101)
Series: Life Sciences Seminar
Host: Florian Schur
Contact: MARR Lena
Lab building west seminar room

Abstract:

Ras and many other proteins that are oncogenic, i.e., associated with cancer when mutated, are allosteric switches. The growing power of gene synthesis and next-generation sequencing can be harnessed to yield insights into molecular mechanism in a novel way. I will cover the application of high-throughput mutagenesis to Ras, combined with structural analysis and molecular dynamics simulations, with an emphasis on understanding the allosteric mechanisms that lead to mutational sensitivity.
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