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Understanding Ras Sensitivity to Mutation by High-Throughput Mutagenesis

Date: Tuesday, June 4, 2019 14:00 - 15:30
Speaker: John Kuriyan (Howard Hughes Medical Institute Departments of Molecular & Cell Biology and Department of Chemistry, UC Berkely)
Location: Big Seminar room Ground floor / Office Bldg West (I21.EG.101)
Series: Life Sciences Seminar
Host: Florian Schur
Contact: MARR Lena
Lab building west seminar room

Ras and many other proteins that are oncogenic, i.e., associated with cancer when mutated, are allosteric switches. The growing power of gene synthesis and next-generation sequencing can be harnessed to yield insights into molecular mechanism in a novel way. I will cover the application of high-throughput mutagenesis to Ras, combined with structural analysis and molecular dynamics simulations, with an emphasis on understanding the allosteric mechanisms that lead to mutational sensitivity.
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