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New regulators of adhesion and cytoskeletal dynamics in cell migration

Date: Friday, August 16, 2019 10:00 - 11:00
Speaker: Johanna Ivaska (University of Turku)
Location: Mondi Seminar Room 2, Central Building
Series: Life Sciences Seminar
Host: Michael Sixt
Contact: Kopf Aglaja

Abstract:

We are interested in understanding how integrins contribute to cancer cell migration, invasion, tumour-stroma crosstalk and other processes that promote cancer progression. Current projects in the lab focus on finding novel regulators of integrin activity, understanding the endo/exosomal traffic of integrins and how cancer cells sense their microenvironment, where biophysical cues from the stroma determine cancer cell fate. This talk will be about about our recent unpublished work on MASTL regulating the cytoskeleton through SRF/MRTF and GEFH-1 and SHANK-mediated regulation of the actin cytoskeleton and adhesion turnover.
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