Cellular drivers of injury response and regeneration in the zebrafish heart
Date:
Friday, April 23, 2021 15:00 - 16:00
Speaker:
Jan Philipp Junker (Max Delbrück Center, Berlin Institute for Medical Systems Biology)
Location:
https://istaustria.zoom.us/j/96694528178?pwd=bnU1M09idWlLOXFZRlFIb2tWbzRxZz09
Series:
FriSBi
Host:
Anna Kicheva
Contact:
BONVENTRE-DARTHE Astrid
We recently developed LINNAEUS, a CRISPR/Cas9-based method for simultaneous transcriptome profiling and lineage tracing of thousands of single cells. Here, we use this approach to reveal principles of heart regeneration in adult zebrafish. We identify the origin and function of transient pro-regenerative cell states that are generated upon injury, and we determine mechanisms of cell type activation.