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Voltage-gated proton channels: "When too much of a good thing is a disease"

Date: Thursday, September 21, 2017 17:00 - 18:00
Speaker: Francesco Tombola (UC Irvine)
Location: Seminar Room, Lab Building East
Series: Life Sciences Seminar
Host: Harald Janovjak
Contact: MALLY Alexandra
Lab building east seminar room

Abstract:

Voltage-gated proton channels (Hvs) are expressed in tissues throughout the body and play important roles in pH homeostasis and in the regulation of NOX enzymes. They consist of two proton-permeable voltage-sensing domains linked together by a cytoplasmic coiled-coil domain. Their voltage-dependent activation is affected by a variety of stimuli, including transmembrane pH gradients, mechanical force, and temperature. Excessive proton channel activity has pathological consequences, such as increased invasiveness in cancer, and enhanced brain damage in ischemic stroke. In this presentation, I will discuss the physiological and pathological functions of Hv channels, as well as our efforts to elucidate their mechanism of activation and to develop small-molecule inhibitors that could find applications as anticancer drugs and neuroprotective agents.

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